Semaglutide

Products Description

Semaglutide CAS No. 910463-68-2

Semaglutide has a chemical structure that is very similar to the hormone glucagon-like peptide 1 (GLP-1), adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.

Semaglutide may help people with obesity lose weight as well.

Function

Semaglutide is the newest GLP-1R agonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2017. The peptide is chemically similar to liraglutide, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to liraglutide, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans.

Application

Weight loss 

Anti-diabetes

Alzheimer's disease